SCG2 Gene Summary [Human]
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SCG2 |
| Official Name | secretogranin II [Source:HGNC Symbol;Acc:HGNC:10575] |
| Ensembl ID | ENSG00000171951 |
| Bio databases IDs | |
| Aliases | secretogranin II, secretoneurin, chromogranin C |
| Synonyms | Chcg, CHGC, EM66, PRO-SN, Secretogranin 2, SECRETOGRANIN II, Secretoneurin, Sg2, SgII, SN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemoattractant
- Granin (chromogranin or secretogranin)
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- depressive disorder
- systemic lupus erythematosus
- oral squamous cell carcinoma
- Huntington disease
- squamous cell cancer of the oral cavity
- leiomyoma
- leiomyomatosis
- corneal neovascularization
- diabetes mellitus
role in cell
- expression in
- apoptosis
- phosphorylation in
- migration
- proliferation
- differentiation
- chemotaxis
- tubulation
- signal transduction in
- chemoattraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- dense core secretory granule fraction
- Cytoplasm
- vesicles
- Golgi Apparatus
- granules
- endoplasmic reticulum lumen
- dense-core vesicles
- secretory vesicles
- secretory granules
- membrane processes
- immature secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- endothelial cell migration
- protein secretion
- MAPK cascade
- inflammatory response
- angiogenesis
- eosinophil chemotaxis
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of endothelial cell proliferation
- positive regulation of endothelial cell proliferation
- negative regulation of endothelial cell apoptotic process
- intracellular signal transduction
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- secretory granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemoattractant activity
- cytokine activity