Scg2 Gene Summary [Mouse]
Predicted to enable chemoattractant activity and cytokine activity. Involved in angiogenesis. Located in dense core granule. Is active in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCG2 (secretogranin II). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scg2 |
| Official Name | secretogranin II [Source:MGI Symbol;Acc:MGI:103033] |
| Ensembl ID | ENSMUSG00000050711 |
| Bio databases IDs | |
| Aliases | secretogranin II |
| Synonyms | Chcg, CHGC, EM66, PRO-SN, Secretogranin 2, SECRETOGRANIN II, Secretoneurin, Sg2, SgII, SN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemoattractant
- Granin (chromogranin or secretogranin)
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- depressive disorder
- systemic lupus erythematosus
- oral squamous cell carcinoma
- Huntington disease
- squamous cell cancer of the oral cavity
- leiomyoma
- leiomyomatosis
- corneal neovascularization
- diabetes mellitus
role in cell
- expression in
- apoptosis
- phosphorylation in
- migration
- proliferation
- differentiation
- chemotaxis
- tubulation
- signal transduction in
- chemoattraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- dense core secretory granule fraction
- Cytoplasm
- vesicles
- Golgi Apparatus
- granules
- endoplasmic reticulum lumen
- dense-core vesicles
- secretory vesicles
- secretory granules
- membrane processes
- immature secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- endothelial cell migration
- protein secretion
- MAPK cascade
- inflammatory response
- angiogenesis
- eosinophil chemotaxis
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of endothelial cell proliferation
- positive regulation of endothelial cell proliferation
- negative regulation of endothelial cell apoptotic process
- intracellular signal transduction
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- secretory granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemoattractant activity
- cytokine activity