CCL19 Gene Summary [Human]
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCL19 |
| Official Name | C-C motif chemokine ligand 19 [Source:HGNC Symbol;Acc:HGNC:10617] |
| Ensembl ID | ENSG00000172724 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 19, CC chemokine ligand 19, macrophage inflammatory protein 3-beta, beta chemokine exodus-3, CK beta-11, EBI1-ligand chemokine |
| Synonyms | C-C motif chemokine ligand 19, CCR7 LIGAND, CKb11, CK β-11, ELC, exodus-3, Gm2023, MIP-3b, MIP3 beta, MIP3 β, SCYA19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCL19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL19 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- gastric cancer
- lung cancer
- epithelial cancer
- lymphomagenesis
- liver cancer
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- accumulation in
- expression in
- quantity
- proliferation
- cell death
- apoptosis
- phosphorylation in
- cellular infiltration by
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- vesicles
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCL19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T-helper 1 cell differentiation
- positive regulation of JUN kinase activity
- positive regulation of glycoprotein biosynthetic process
- response to prostaglandin E stimulus
- cell communication
- positive regulation of endocytosis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to virus
- positive regulation of GTPase activity
- immunological synapse formation
- cell chemotaxis
- inflammatory response
- immune response
- mature dendritic cell differentiation
- establishment of T cell polarity
- positive regulation of tumor necrosis factor production
- response to nitric oxide
- release of sequestered calcium ion into cytosol
- positive regulation of receptor-mediated endocytosis
- T cell costimulation
- regulation of cell projection assembly
- positive regulation of neutrophil chemotaxis
- cell maturation
- positive regulation of T cell proliferation
- cellular calcium ion homeostasis
- positive regulation of interleukin-12 production
- negative regulation of dendritic cell apoptotic process
- positive regulation of protein kinase activity
- positive regulation of JNK cascade
- positive regulation of dendritic cell dendrite assembly
- chemokine-mediated signaling pathway
- dendritic cell chemotaxis
- positive regulation of ERK1 and ERK2 cascade
- myeloid dendritic cell chemotaxis
- positive regulation of dendritic cell antigen processing and presentation
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- positive regulation of interleukin-1 beta production
- positive regulation of cell migration
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR10 chemokine receptor binding
- protein binding
- CCR chemokine receptor binding
- CCR7 chemokine receptor binding
- chemokine activity
- chemokine receptor binding