CCR7 Gene Summary [Human]
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCR7 |
| Official Name | C-C motif chemokine receptor 7 [Source:HGNC Symbol;Acc:HGNC:1608] |
| Ensembl ID | ENSG00000126353 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine receptor 7 |
| Synonyms | BLR2, CC-CKR-7, C-C motif chemokine receptor 7, CD197, CDw197, CHEMOKINE CC7 receptor, CMKBR7, EBI1, Ebi1h |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCR7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CCR7 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- Communication between Innate and Adaptive Immune Cells
- CREB Signaling in Neurons
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- experimental autoimmune encephalomyelitis
- mycosis fungoides
- metastasis
- abdominal aortic aneurysm
- Sjögren syndrome
- organismal death
- skin cancer
- tuberculosis
role in cell
- formation
- apoptosis
- production in
- phosphorylation in
- polarization
- activation in
- adhesion
- assembly
- quantity
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Mitochondria
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCR7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemokine (C-C motif) ligand 21 signaling pathway
- chemokine (C-C motif) ligand 19 signaling pathway
- response to prostaglandin E stimulus
- positive regulation of filopodium assembly
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of cell adhesion
- cell chemotaxis
- regulation of interferon-gamma production
- lymphocyte migration into lymph node
- inflammatory response
- immune response
- establishment of T cell polarity
- mature dendritic cell differentiation
- positive regulation of dendritic cell chemotaxis
- release of sequestered calcium ion into cytosol
- response to nitric oxide
- calcium-mediated signaling
- G-protein coupled receptor signaling pathway
- positive regulation of pseudopodium assembly
- positive regulation of neutrophil chemotaxis
- elevation of cytosolic calcium ion concentration
- positive regulation of T cell receptor signaling pathway
- positive regulation of hypersensitivity
- positive regulation of interleukin-12 production
- regulation of dendritic cell dendrite assembly
- positive regulation of T cell costimulation
- positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
- negative regulation of dendritic cell apoptotic process
- positive regulation of cell-matrix adhesion
- positive regulation of protein kinase activity
- positive regulation of humoral immune response
- positive regulation of JNK cascade
- ruffle organization
- homeostasis of number of cells
- dendritic cell chemotaxis
- positive regulation of actin filament polymerization
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of dendritic cell antigen processing and presentation
- myeloid dendritic cell chemotaxis
- positive regulation of immunological synapse formation
- cellular response to cytokine stimulus
- response to lipopolysaccharide
- regulation of interleukin-1 beta production
- negative regulation of interleukin-12 production
- negative thymic T cell selection
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- C-C motif chemokine 21 receptor activity
- C-C chemokine receptor activity
- chemokine (C-C motif) ligand 19 binding
- chemokine (C-C motif) ligand 21 binding
- C-C motif chemokine 19 receptor activity