TRMT112 Gene Summary [Human]
Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TRMT112 |
| Official Name | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] |
| Ensembl ID | ENSG00000173113 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase subunit 11-2, tRNA methyltransferase activator subunit 11-2 |
| Synonyms | 0610038D11Rik, HSPC152, HSPC170, hTrm112, RGD1309710, TRM112, Trm112p, tRNA methyltransferase 11-2, tRNA methyltransferase activator subunit 11-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRMT112 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- enzyme
- protein binding
- enzyme regulator activity
- enzyme activator activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear Golgi regions
- perinuclear region
- lysosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRMT112 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- rRNA methylation
- positive regulation of rRNA processing
- peptidyl-glutamine methylation
- rRNA (guanine-N7)-methylation
- tRNA methylation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein methyltransferase activity
- protein heterodimerization activity