Trmt112 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in peptidyl-glutamine methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trmt112 |
| Official Name | tRNA methyltransferase 11-2 [Source:MGI Symbol;Acc:MGI:1914924] |
| Ensembl ID | ENSMUSG00000038812 |
| Bio databases IDs | |
| Aliases | tRNA methyltransferase 11-2 |
| Synonyms | 0610038D11Rik, HSPC152, HSPC170, hTrm112, RGD1309710, TRM112, Trm112p, tRNA methyltransferase 11-2, tRNA methyltransferase activator subunit 11-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmt112 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- enzyme
- protein binding
- enzyme regulator activity
- enzyme activator activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear Golgi regions
- perinuclear region
- lysosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmt112 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- rRNA methylation
- positive regulation of rRNA processing
- peptidyl-glutamine methylation
- rRNA (guanine-N7)-methylation
- tRNA methylation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein methyltransferase activity
- protein heterodimerization activity