METTL5 Gene Summary [Human]
Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation and rRNA methylation. Located in nucleus; postsynapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder-72. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | METTL5 |
| Official Name | methyltransferase like 5 [Source:HGNC Symbol;Acc:HGNC:25006] |
| Ensembl ID | ENSG00000138382 |
| Bio databases IDs | |
| Aliases | methyltransferase like 5, methyltransferase 5, N6-adenosine |
| Synonyms | 2810410A08Rik, HSPC133, LOC100046143, methyltransferase 5, N6-adenosine, MRT72, RGD1566062 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (adenine-N6-)-methyltransferase
- binding protein
- enzyme
- protein binding
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive intellectual developmental disorder 72
- organismal death
- craniofacial abnormality
role in cell
- binding in
- differentiation
- translation in
- pluripotency
- N6-methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- presynaptic regions
- postsynaptic region
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- stem cell differentiation
- rRNA methylation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- cell projection
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- rRNA (adenine-N6-)-methyltransferase activity