ETF1 Gene Summary [Human]
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | ETF1 |
| Official Name | eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:HGNC:3477] |
| Ensembl ID | ENSG00000120705 |
| Bio databases IDs | |
| Aliases | eukaryotic translation termination factor 1, sup45 (yeast omnipotent suppressor 45) homolog-like 1, polypeptide chain release factor 1 |
| Synonyms | AI463371, Cl1, D5S1995, D6Ertd109e, ERF, ERF1, eukaryotic translation termination factor 1, MGC18745, RF1, SUP45L1, TB3-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ETF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eRF1 domain 3
- mRNA binding
- aminoacyl-tRNA hydrolase
- eRF1 domain 1
- ribosome binding
- translation termination factor
- peptide chain release factor 1, archaeal and eukaryotic forms
- protein binding
- eRF1 domain 2
- translation release factor
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ETF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational termination
- regulation of translational termination
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- cytoplasmic translational termination
- protein methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
- cytosol
- translation release factor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation release factor activity
- ribosome binding
- aminoacyl-tRNA hydrolase activity
- translation termination factor activity
- translation release factor activity, codon specific