ADGRG2 Gene Summary [Human]

This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Details

Type
Protein Coding
Official Symbol
ADGRG2
Official Name
adhesion G protein-coupled receptor G2 [Source:HGNC Symbol;Acc:HGNC:4516]
Ensembl ID
ENSG00000173698
Bio databases IDs NCBI: 10149 Ensembl: ENSG00000173698
Aliases adhesion G protein-coupled receptor G2, epididymal protein 6
Synonyms adhesion G protein-coupled receptor G2, AW212196, B830041D06Rik, CBAVDX, EDDM6, GPR64, HE6, Me6, Re6, TM7LN2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • 7 transmembrane receptor (Secretin family)
  • GPCR proteolysis site, GPS, motif
  • protein binding
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the ADGRG2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • congenital bilateral aplasia of vas deferens
  • Ewing sarcoma
  • osteosarcomagenesis
  • X-linked congenital bilateral aplasia of vas deferens
  • organismal death
  • Wilms tumor
  • Wilms tumorigenesis
regulated by
role in cell
  • proliferation
  • migration
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • cytosol
  • apical membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ADGRG2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • G-protein coupled receptor signaling pathway
  • spermatogenesis
  • cell surface receptor signaling pathway
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • membrane
  • cytosol
  • apical plasma membrane
  • plasma membrane
  • cell surface

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.