PHC3 Gene Summary [Human]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of PRC1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PHC3 |
| Official Name | polyhomeotic homolog 3 [Source:HGNC Symbol;Acc:HGNC:15682] |
| Ensembl ID | ENSG00000173889 |
| Bio databases IDs | |
| Aliases | polyhomeotic homolog 3, early development regulator 3, polyhomeotic like 3 |
| Synonyms | E030046K01Rik, EDR3, HPH3, polyhomeotic 3, polyhomeotic homolog 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- transcription regulator
- SAM (Sterile alpha motif )
- protein binding
Pathways
Biological processes and signaling networks where the PHC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- histone binding
- chromatin binding