CIZ1 Gene Summary [Human]
The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | CIZ1 |
| Official Name | CDKN1A interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:16744] |
| Ensembl ID | ENSG00000148337 |
| Bio databases IDs | |
| Aliases | CDKN1A interacting zinc finger protein 1 |
| Synonyms | 0610038H21Rik, 2900056O04Rik, CDKN1A interacting zinc finger protein 1, LSFR1, NP94, ZNF356 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIZ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Zinc-finger double-stranded RNA-binding
- U1 zinc finger
- protein binding
- transporter
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- hyperplasia
role in cell
- growth
- expression in
- accumulation in
- proliferation
- S phase
- sensitivity
- synthesis in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIZ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA-dependent DNA replication initiation
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- cyclin binding