Klhl15 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl15 |
| Official Name | kelch-like 15 [Source:MGI Symbol;Acc:MGI:1923400] |
| Ensembl ID | ENSMUSG00000043929 |
| Bio databases IDs | |
| Aliases | kelch-like 15 |
| Synonyms | 6330500C13Rik, HEL-S-305, kelch-like 15, kelch-like family member 15, RGD1563101, XLID103 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation
- X-linked mental retardation type 103
role in cell
- damage in
- stabilization in
- turnover in
- ubiquitination in
- complexity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of double-strand break repair via homologous recombination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding