MSRB3 Gene Summary [Human]
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | MSRB3 |
| Official Name | methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375] |
| Ensembl ID | ENSG00000174099 |
| Bio databases IDs | |
| Aliases | methionine sulfoxide reductase B3 |
| Synonyms | D430026P16Rik, DFNB74, I-8-23, LOC253827, methionine sulfoxide reductase B3, methionine sulphoxide reductase B3, MsrB2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MSRB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- sulfur group:disulfide oxidoreductase
- enzyme
- SelR domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obstructive sleep apnea
- sleep apnea syndrome
- autosomal recessive deafness type 74
- preeclampsia
- primary snoring
- insomnia
- autosomal recessive deafness
- hearing loss
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- apoptosis
- degeneration
- abnormal morphology
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MSRB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein repair
- response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- L-methionine-(R)-S-oxide reductase activity
- peptide-methionine (R)-S-oxide reductase activity