Msrb3 Gene Summary [Mouse]
Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; inner ear; jaw; limb; and skeleton. Used to study autosomal recessive nonsyndromic deafness 74. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msrb3 |
| Official Name | methionine sulfoxide reductase B3 [Source:MGI Symbol;Acc:MGI:2443538] |
| Ensembl ID | ENSMUSG00000051236 |
| Bio databases IDs | |
| Aliases | methionine sulfoxide reductase B3 |
| Synonyms | D430026P16Rik, DFNB74, I-8-23, LOC253827, methionine sulfoxide reductase B3, methionine sulphoxide reductase B3, MsrB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msrb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- sulfur group:disulfide oxidoreductase
- enzyme
- SelR domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obstructive sleep apnea
- sleep apnea syndrome
- autosomal recessive deafness type 74
- preeclampsia
- primary snoring
- insomnia
- autosomal recessive deafness
- hearing loss
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- apoptosis
- degeneration
- abnormal morphology
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msrb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein repair
- response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- L-methionine-(R)-S-oxide reductase activity
- peptide-methionine (R)-S-oxide reductase activity