ZHX3 Gene Summary [Human]
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZHX3 |
| Official Name | zinc fingers and homeoboxes 3 [Source:HGNC Symbol;Acc:HGNC:15935] |
| Ensembl ID | ENSG00000174306 |
| Bio databases IDs | |
| Aliases | zinc fingers and homeoboxes 3 |
| Synonyms | 1810059C13Rik, 4932418O04Rik, 9530010N21Rik, KIAA0395, LOC102551402, mKIAA0395, TIX1, Triple homeobox1, zinc fingers and homeoboxes 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZHX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-fingers and homeoboxes C2H2 finger domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein homodimerization
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- non-insulin-dependent diabetes mellitus
- myocardial infarction
- major depression
- Alzheimer disease
- mood disorder
- coronary artery disease
- male pattern hair loss
- hyperlipidemia
- migraines
regulates
- DNA promoter
- RNA polymerase II
- DNA endogenous promoter
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell cortex
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZHX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- cell differentiation
- positive regulation of osteoblast differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity