NPAS4 Gene Summary [Human]
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NPAS4 |
| Official Name | neuronal PAS domain protein 4 [Source:HGNC Symbol;Acc:HGNC:18983] |
| Ensembl ID | ENSG00000174576 |
| Bio databases IDs | |
| Aliases | neuronal PAS domain protein 4 |
| Synonyms | bHLHe79, LE-PAS, neuronal PAS domain protein 4, NXF, PASD10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPAS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gliosis
- myoclonus
role in cell
- expression in
- cell death
- phosphorylation in
- number
- abnormal morphology
- response by
- degeneration
- production in
- transactivation in
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPAS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- regulation of excitatory postsynaptic membrane potential
- learning
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- long-term memory
- short-term memory
- cellular response to corticosterone stimulus
- regulation of synaptic plasticity
- cell differentiation
- regulation of inhibitory postsynaptic membrane potential
- regulation of synaptic transmission, GABAergic
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity