Npas4 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including chemical postsynaptic transmission; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; future forebrain; and urinary system. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Npas4 |
| Official Name | neuronal PAS domain protein 4 [Source:MGI Symbol;Acc:MGI:2664186] |
| Ensembl ID | ENSMUSG00000045903 |
| Bio databases IDs | |
| Aliases | neuronal PAS domain protein 4 |
| Synonyms | bHLHe79, LE-PAS, neuronal PAS domain protein 4, NXF, PASD10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npas4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gliosis
- myoclonus
role in cell
- expression in
- cell death
- phosphorylation in
- number
- abnormal morphology
- response by
- degeneration
- production in
- transactivation in
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npas4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- regulation of excitatory postsynaptic membrane potential
- learning
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- long-term memory
- short-term memory
- cellular response to corticosterone stimulus
- regulation of synaptic plasticity
- cell differentiation
- regulation of inhibitory postsynaptic membrane potential
- regulation of synaptic transmission, GABAergic
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity