RESF1 Gene Summary [Human]
Predicted to enable histone binding activity and histone methyltransferase binding activity. Predicted to be involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleus. Predicted to colocalize with gamma-tubulin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | RESF1 |
| Official Name | retroelement silencing factor 1 [Source:HGNC Symbol;Acc:HGNC:25559] |
| Ensembl ID | ENSG00000174718 |
| Bio databases IDs | |
| Aliases | retroelement silencing factor 1, gonad expressed transcript |
| Synonyms | 2810474O19Rik, 6720435I21Rik, C12orf35, FLJ10652, FLJ20696, GET, KIAA1551, retroelement silencing factor 1, RGD1309621, UTA2-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RESF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Domain of unknown function (DUF4617)
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RESF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of retroviral genome replication
- positive regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- gamma-tubulin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding