Resf1 Gene Summary [Mouse]
Enables histone methyltransferase binding activity. Involved in transposable element silencing by heterochromatin formation. Acts upstream of or within response to bacterium. Located in nucleus. Is expressed in genitourinary system; limb; and somite. Orthologous to human RESF1 (retroelement silencing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Resf1 |
| Official Name | retroelement silencing factor 1 [Source:MGI Symbol;Acc:MGI:1914496] |
| Ensembl ID | ENSMUSG00000032712 |
| Bio databases IDs | |
| Aliases | retroelement silencing factor 1 |
| Synonyms | 2810474O19Rik, 6720435I21Rik, C12orf35, FLJ10652, FLJ20696, GET, KIAA1551, retroelement silencing factor 1, RGD1309621, UTA2-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Resf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Domain of unknown function (DUF4617)
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Resf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of retroviral genome replication
- positive regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- gamma-tubulin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding