EXOC1 Gene Summary [Human]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
EXOC1
Official Name
exocyst complex component 1 [Source:HGNC Symbol;Acc:HGNC:30380]
Ensembl ID
ENSG00000090989
Bio databases IDs NCBI: 55763 Ensembl: ENSG00000090989
Aliases exocyst complex component 1
Synonyms 2810407P21RIK, A730011E05Rik, BM-102, exocyst complex component 1, SEC3, SEC3L1, SEC3P
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Exocyst complex component Sec3
  • protein binding
  • Pleckstrin homology-like domain
  • transporter
  • Exocyst complex component SEC3 N-terminal PIP2 binding PH

Pathways

Biological processes and signaling networks where the EXOC1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cervical carcinoma
  • epithelial uterine cancer
  • cervical cancer
regulated by
  • guanosine triphosphate
  • QKI
  • kanamycin A
  • vancomycin
  • metronidazole
  • colistin
  • gentamicin
  • NEK2
  • NCAM1
  • FGFR
regulates
  • tubulin

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human EXOC1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane fission
  • cytokinesis after mitosis
  • vesicle docking involved in exocytosis
  • protein transport
  • Golgi to plasma membrane transport
  • regulation of macroautophagy
  • defense response to virus
  • exocytosis

Cellular Component

Where in the cell the gene product is active
  • perinuclear region of cytoplasm
  • cytoplasm
  • membrane
  • cytosol
  • plasma membrane
  • exocyst

Molecular Function

What the gene product does at the molecular level
  • phosphatidylinositol-4,5-bisphosphate binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

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