CSRP2 Gene Summary [Human]
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | CSRP2 |
| Official Name | cysteine and glycine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2470] |
| Ensembl ID | ENSG00000175183 |
| Bio databases IDs | |
| Aliases | cysteine and glycine rich protein 2 |
| Synonyms | CRP2, cysteine and glycine-rich protein 2, LMO5, SmLIM, Smooth Muscle Cell Lim |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSRP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- insulin resistance
- juvenile dermatomyositis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- schizophrenia
- glioblastoma
- glioblastoma cancer
- Duchenne muscular dystrophy
- Huntington disease
role in cell
- abnormal morphology
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSRP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
- cell differentiation
- muscle tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- metal ion binding
- actinin binding