Csrp2 Gene Summary [Mouse]
Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development and sarcomere organization. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; cranium; genitourinary system; and gut. Orthologous to human CSRP2 (cysteine and glycine rich protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csrp2 |
| Official Name | cysteine and glycine-rich protein 2 [Source:MGI Symbol;Acc:MGI:1202907] |
| Ensembl ID | ENSMUSG00000020186 |
| Bio databases IDs | |
| Aliases | cysteine and glycine-rich protein 2 |
| Synonyms | CRP2, cysteine and glycine-rich protein 2, LMO5, SmLIM, Smooth Muscle Cell Lim |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- insulin resistance
- juvenile dermatomyositis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- schizophrenia
- glioblastoma
- glioblastoma cancer
- Duchenne muscular dystrophy
- Huntington disease
role in cell
- abnormal morphology
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
- cell differentiation
- muscle tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- metal ion binding
- actinin binding