MED16 Gene Summary [Human]
Enables thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MED16 |
| Official Name | mediator complex subunit 16 [Source:HGNC Symbol;Acc:HGNC:17556] |
| Ensembl ID | ENSG00000175221 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 16 |
| Synonyms | A630083L04, DRIP92, MED95, mediator complex subunit 16, THRAP5, TRAP95 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- WD40 repeats
- WD domain, G-beta repeat
- Mediator complex subunit 16
- WD40
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the MED16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- syndromic mental retardation
role in cell
- proliferation
- phosphorylation in
- expression in
- G1 phase
- migration
- radioiodine resistance
- 4-hydroxy tamoxifen sensitivity
- upregulation in
- downregulation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding