MED14 Gene Summary [Human]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MED14 |
| Official Name | mediator complex subunit 14 [Source:HGNC Symbol;Acc:HGNC:2370] |
| Ensembl ID | ENSG00000180182 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 14 |
| Synonyms | 9930001L01RIK, CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, Gm641, mediator complex subunit 14, ORF1, RGD1560170, RGR1, TRAP170 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription cofactor
- Proline-rich protein
- protein binding
- Mediator complex subunit MED14
Pathways
Biological processes and signaling networks where the MED14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- primary antiphospholipid antibody syndrome
- Turner syndrome
- allergic rhinitis
- infection by HIV-1
role in cell
- expression in
- production in
- cell death
- cell viability
- adipogenesis
- replication in
- recruitment in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- membrane
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding