P2RY2 Gene Summary [Human]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | P2RY2 |
| Official Name | purinergic receptor P2Y2 [Source:HGNC Symbol;Acc:HGNC:8541] |
| Ensembl ID | ENSG00000175591 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y2 |
| Synonyms | HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2, purinergic receptor P2Y, G-protein coupled 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- UTP-activated nucleotide receptor
- purinergic G-protein coupled nucleotide receptor
- G-protein-coupled receptor binding
- ATP binding
- RGD motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- PXXP motif
Pathways
Biological processes and signaling networks where the P2RY2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- liver neoplasia
- cancer
- weight gain
- dental caries
- pneumonitis
- lung cancer
- thermal hypalgesia
role in cell
- accumulation in
- production in
- expression in
- proliferation
- phosphorylation in
- growth
- migration
- synthesis in
- cellular infiltration by
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- apical membrane
- presynaptic membrane
- basolateral membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of mucus secretion
- cellular response to ATP
- cellular ion homeostasis
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- UTP-activated nucleotide receptor activity
- protein binding
- signaling receptor activity
- G-protein coupled purinergic nucleotide receptor activity
- A1 adenosine receptor binding