TNPO3 Gene Summary [Human]
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]
Details
| Type | Protein Coding |
| Official Symbol | TNPO3 |
| Official Name | transportin 3 [Source:HGNC Symbol;Acc:HGNC:17103] |
| Ensembl ID | ENSG00000064419 |
| Bio databases IDs | |
| Aliases | transportin 3, importin 12 |
| Synonyms | 5730544L10Rik, C430013M08RIK, D6Ertd313e, IPO12, LGMD1F, LGMDD2, mKIAA4133, MTR10A, NUCLEAR TRANSPORT receptor, transportin 3, Transportin-SR, TRN-SR, TRN-SR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNPO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exportin 1-like protein
- alpha helix
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- identical protein binding
- cargo binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- hypothyroidism
- limb-girdle muscular dystrophy type 1F
- leiomyomatosis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- systemic sclerosis
- systemic lupus erythematosus
- primary biliary cirrhosis
- myositis
role in cell
- expression in
- migration
- proliferation
- quantity
- integration in
- differentiation
- nuclear import in
- replication in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endomembrane system
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNPO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytoplasm
- intracellular membrane-bounded organelle
- annulate lamellae
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- small GTPase binding