CRLF3 Gene Summary [Human]
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Details
| Type | Processed Transcript |
| Official Symbol | CRLF3 |
| Official Name | cytokine receptor like factor 3 [Source:HGNC Symbol;Acc:HGNC:17177] |
| Ensembl ID | ENSG00000176390 |
| Bio databases IDs | |
| Aliases | cytokine receptor like factor 3 |
| Synonyms | BB164954, CREME-9, CRLM9, cytokine receptor-like factor 3, CYTOR4, FRWS, p48.2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRLF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription regulator
- B-Box C-terminal domain
- FN3
- protein binding
- Fibronectin type 3 domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- localized cutaneous leishmaniasis
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- apoptosis
- survival
- growth
- length
- maturation
- number
- formation
- branching in
- branching
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRLF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding