PIAS4 Gene Summary [Human]
Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIAS4 |
| Official Name | protein inhibitor of activated STAT 4 [Source:HGNC Symbol;Acc:HGNC:17002] |
| Ensembl ID | ENSG00000105229 |
| Bio databases IDs | |
| Aliases | protein inhibitor of activated STAT 4, zinc finger, MIZ-type containing 6 |
| Synonyms | Piasg, PIAS-gamma, PIASY, PIAS-γ, protein inhibitor of activated STAT 4, protein inhibitor of activated STAT, 4, ZMIZ6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIAS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PINIT domain
- SUMO ligase
- ubiquitin protein ligase binding
- transcription regulator
- SAP motif
- SUMO transferase activity
- transcription co-repressor
- protein binding
- DNA binding
- ring like zinc finger domain
- transcription repression domain
- serine-rich region
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
Pathways
Biological processes and signaling networks where the PIAS4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute coronary syndrome
- metabolic syndrome X
- refractive error
- idiopathic scoliosis
- rhabdomyolysis
role in cell
- activation in
- cell death
- expression in
- transcription in
- binding in
- ubiquitination in
- apoptosis
- recruitment in
- survival
- repopulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- nuclear speckles
- nuclear matrix
- PML nuclear bodies
- chromosomal arms
- chromosomal cores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIAS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- regulation of mRNA stability
- limb epidermis development
- double-strand break repair
- regulation of transcription from RNA polymerase II promoter
- vitamin D metabolic process
- negative regulation of transcription from RNA polymerase II promoter
- central nervous system development
- hair follicle development
- negative regulation of transcription, DNA-dependent
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of protein sumoylation
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- ubiquitin protein ligase binding
- transcription cofactor activity
- protein binding
- transcription corepressor activity
- SUMO ligase activity