SLCO3A1 Gene Summary [Human]
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLCO3A1 |
| Official Name | solute carrier organic anion transporter family member 3A1 [Source:HGNC Symbol;Acc:HGNC:10952] |
| Ensembl ID | ENSG00000176463 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 3A1 |
| Synonyms | 5830414C08Rik, Anr1, MJAM, OATP3A1, OATP-D, OATP-RP3, SLC21A11, solute carrier organic anion transporter family member 3A1, solute carrier organic anion transporter family, member 3a1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO3A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- protein binding
- KAZAL_FS
- organic anion transporter
- prostaglandin transporter
- transporter
Pathways
Biological processes and signaling networks where the SLCO3A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nausea
- severe acute respiratory syndrome
- dementia
- restless legs syndrome
- metabolic syndrome X
- immunological disorder
- paroxysmal nocturnal hemoglobinuria
- glioblastoma
- glioblastoma cancer
- acute lymphoblastic leukemia
regulates
- 3-iodothyronamine
- prostaglandin
- SLCO3A1 substrates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO3A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- positive regulation of protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity