PHETA2 Gene Summary [Human]
Enables protein homodimerization activity. Involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Located in cytoplasmic vesicle and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PHETA2 |
| Official Name | PH domain containing endocytic trafficking adaptor 2 [Source:HGNC Symbol;Acc:HGNC:27161] |
| Ensembl ID | ENSG00000177096 |
| Bio databases IDs | |
| Aliases | PH domain containing endocytic trafficking adaptor 2, Sesquipedalian-2, inositol polyphosphate phosphatase-interacting protein B |
| Synonyms | C920005C14Rik, FAM109B, IPIP27B, LOC687232, PH domain containing endocytic trafficking adaptor 2, Ses2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHETA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein homodimerization
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- trans Golgi network
- recycling endosomes
- early endosomes
- clathrin-coated vesicles
- perinuclear recycling endosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHETA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- retrograde transport, endosome to Golgi
- receptor recycling
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- early endosome
- cytosol
- recycling endosome
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding