RIC8B Gene Summary [Human]
Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RIC8B |
| Official Name | RIC8 guanine nucleotide exchange factor B [Source:HGNC Symbol;Acc:HGNC:25555] |
| Ensembl ID | ENSG00000111785 |
| Bio databases IDs | |
| Aliases | RIC8 guanine nucleotide exchange factor B |
| Synonyms | HSYN, RIC8, RIC8 guanine nucleotide exchange factor B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIC8B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar basal body rod FlgEFG protein C-terminal
- guanyl-nucleotide exchange factor
- protein binding
- Guanine nucleotide exchange factor synembryn
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIC8B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cell cortex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein alpha-subunit binding
- guanyl-nucleotide exchange factor activity