RNF138 Gene Summary [Human]
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF138 |
| Official Name | ring finger protein 138 [Source:HGNC Symbol;Acc:HGNC:17765] |
| Ensembl ID | ENSG00000134758 |
| Bio databases IDs | |
| Aliases | ring finger protein 138, nemo-like kinase associated ring finger protein |
| Synonyms | 2410015A17Rik, 2810480D20Rik, hNARF, HSD-4, ring finger protein 138, RSD-4, STRIN, Trif, Trif-d |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF138 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Drought induced 19 protein (Di19), zinc-binding
- C2HC Zing finger domain
- protein kinase binding
- RING-type zinc-finger
- single-stranded DNA binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- atopic dermatitis
- oligozoospermia
role in cell
- formation
- formation in
- phosphorylation in
- apoptosis
- expression in
- recruitment
- abnormal morphology
- induction
- homologous recombination repair in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF138 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA double-strand break processing involved in repair via single-strand annealing
- double-strand break repair via homologous recombination
- Wnt receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- metal ion binding
- single-stranded DNA binding