TNP2 Gene Summary [Human]
Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of protein processing; single fertilization; and spermatogenesis, exchange of chromosomal proteins. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TNP2 |
| Official Name | transition protein 2 [Source:HGNC Symbol;Acc:HGNC:11952] |
| Ensembl ID | ENSG00000178279 |
| Bio databases IDs | |
| Aliases | transition protein 2 |
| Synonyms | TP2, transition protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- Nuclear transition protein 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- asthenozoospermia
- teratozoospermia
regulates
role in cell
- formation
- binding
- abnormal morphology
- condensation
- morphology
- motility
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoli
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome reaction
- penetration of zona pellucida
- spermatogenesis
- sperm chromatin condensation
- positive regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- nucleosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding