HKDC1 Gene Summary [Human]
This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | HKDC1 |
| Official Name | hexokinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23302] |
| Ensembl ID | ENSG00000156510 |
| Bio databases IDs | |
| Aliases | hexokinase domain containing 1 |
| Synonyms | AABR07045032.1, FLJ22761, hexokinase domain containing 1, RP92 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HKDC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- PLN02914
- glucokinase
- hexokinase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HKDC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- retinitis pigmentosa type 92
- liver cancer
- nonsyndromic cleft lip and palate
- insomnia
- ulcerative colitis
- early missed abortion
- cirrhosis
- acute-on-chronic liver failure
- gestational diabetes mellitus
regulates
- D-glucose
- triacylglycerol
- glucose-6-phosphate
role in cell
- function
- tricarboxylic acid cycle in
- homeostasis in
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HKDC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucose 6-phosphate metabolic process
- cellular glucose homeostasis
- glycolysis
- glucose metabolic process
- carbohydrate phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- cytoplasm
- mitochondrion
- cytosol
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- glucose binding
- ATP binding
- glucokinase activity
- fructokinase activity