DEFB125
DEFB125 Gene Summary
Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Details
| Type | Processed Transcript |
| Official Symbol | DEFB125 |
| Official Name | defensin beta 125 [Source:HGNC Symbol;Acc:HGNC:18105] |
| Ensembl ID | ENSG00000178591 |
| Bio databases IDs | |
| Aliases | defensin beta 125, beta defensin 25 |
| Synonyms | DEFB-25,Defb26,defensin beta 125,defensin beta 26,defensin β 125,defensin β 26,EG654457,LOC100911232 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- beta-defensin domain found in gallinacin-11 (Gal-11) and gallinacin-13 (Gal-13)
Pathways
Biological processes and signaling networks where the DEFB125 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GJA1
- LMLN
- ZYG11B
- UBR4
- LAMA3
- COL6A1
- RNF123
- ZZEF1
- LRP2
- FUT11
disease
regulated by
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DEFB125 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- innate immune response
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular region