ZYG11B Gene Summary [Human]
Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZYG11B |
| Official Name | zyg-11 family member B, cell cycle regulator [Source:HGNC Symbol;Acc:HGNC:25820] |
| Ensembl ID | ENSG00000162378 |
| Bio databases IDs | |
| Aliases | zyg-11 family member B, cell cycle regulator |
| Synonyms | 1110046I03Rik, 2810482G21Rik, D4Mgi23, Gm431, KIAA1730, mKIAA1730, RGD1307814, ZYG11, zyg-11 family member B, cell cycle regulator, zyg-ll family member B, cell cycle regulator |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZYG11B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZYG11B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- misfolded or incompletely synthesized protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Cul2-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding