PARP10 Gene Summary [Human]
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | PARP10 |
| Official Name | poly(ADP-ribose) polymerase family member 10 [Source:HGNC Symbol;Acc:HGNC:25895] |
| Ensembl ID | ENSG00000178685 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 10 |
| Synonyms | ARTD10, LOC100046469, poly (ADP-ribose) polymerase family, member 10, poly(ADP-ribose) polymerase family member 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- nuclear export signal
- pentosyltransferase
- NAD ADP-ribosyltransferase
- poly ADP ribose polymerase domain
- Poly(ADP-ribose) polymerase catalytic domain
- active site
- transcription factor binding
- enzyme
- protein binding
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- developmental delay
- bipolar I disorder
- polyglandular autoimmune syndrome type 1
- venous thromboembolism
- bipolar disorder
role in cell
- expression in
- proliferation
- transformation
- organization
- mono-ADP-ribosylation in
- recruitment in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of fibroblast proliferation
- negative regulation of protein K63-linked ubiquitination
- protein poly-ADP-ribosylation
- NAD biosynthesis via nicotinamide riboside salvage pathway
- protein auto-ADP-ribosylation
- chromatin organization
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- transcription corepressor activity
- K63-linked polyubiquitin binding
- NAD+ ADP-ribosyltransferase activity