NKX2-3 Gene Summary [Human]
This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | NKX2-3 |
| Official Name | NK2 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:7836] |
| Ensembl ID | ENSG00000119919 |
| Bio databases IDs | |
| Aliases | NK2 homeobox 3 |
| Synonyms | CSX3, NK2.3, NK2 homeobox 3, NKX2.3, NKX2C, NKX4-3, tinman |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKX2-3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- inflammatory bowel disease
- cachexia
- Crohn disease
- ulcerative colitis
- colorectal cancer
role in cell
- quantity
- expression in
- phosphorylation in
- proliferation
- differentiation
- abnormal morphology
- migration
- number
- growth
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKX2-3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gland morphogenesis
- spleen development
- triglyceride metabolic process
- transcription from RNA polymerase II promoter
- lymph node development
- odontogenesis of dentin-containing tooth
- CD4-positive, alpha-beta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- leukocyte homeostasis
- post-embryonic digestive tract morphogenesis
- plasma cell differentiation
- Peyer's patch development
- cell differentiation
- leukocyte migration
- regulation of epithelial cell proliferation
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity