RNF186 Gene Summary [Human]
Enables ubiquitin-protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF186 |
| Official Name | ring finger protein 186 [Source:HGNC Symbol;Acc:HGNC:25978] |
| Ensembl ID | ENSG00000178828 |
| Bio databases IDs | |
| Aliases | ring finger protein 186, hypothetical protein FLJ20225 |
| Synonyms | 9130020G10Rik, LOC684585, ring finger protein 186 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF186 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF186 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K29-linked ubiquitination
- protein localization in mitochondrion
- regulation of autophagic vacuole assembly
- protein K63-linked ubiquitination
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding