TOLLIP Gene Summary [Human]
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | TOLLIP |
| Official Name | toll interacting protein [Source:HGNC Symbol;Acc:HGNC:16476] |
| Ensembl ID | ENSG00000078902 |
| Bio databases IDs | |
| Aliases | toll interacting protein |
| Synonyms | 4930403G24Rik, 4931428G15Rik, IL-1RAcPIP, LOC105376512, toll interacting protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOLLIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- kinase binding
- enzyme binding
- protein binding
- receptor binding
- Protein kinase C conserved region 2 (CalB)
- interleukin-1, Type I receptor binding
- C2 domain
Pathways
Biological processes and signaling networks where the TOLLIP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- metastasis
- hepatocellular carcinoma
- organismal death
- familial idiopathic pulmonary fibrosis
- idiopathic pulmonary fibrosis
- peroxisomal acyl CoA oxidase deficiency
role in cell
- degradation in
- expression in
- production in
- internalization in
- accumulation in
- cell death
- activation in
- proliferation
- quantity
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- azurophil granule lumen
- Extracellular Space
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- cytoplasmic aggregates
- cytosol
- nuclear bodies
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOLLIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- inflammatory response
- leukocyte activation
- signal transduction
- protein localization in endosome
- autophagy
- innate immune response
- positive regulation of protein sumoylation
- interleukin-1-mediated signaling pathway
- phosphorylation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome
- perinuclear region of cytoplasm
- nuclear body
- extracellular vesicular exosome
- specific granule lumen
- cytoplasm
- cytosol
- macromolecular complex
- extracellular region
- extrinsic to plasma membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- ubiquitin conjugating enzyme binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- interleukin-1, Type I receptor binding
- Toll-like receptor binding
- kinase binding
- binding, bridging