Rnf186 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of with a positive effect on regulation of autophagosome assembly. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver and biliary system; and musculoskeletal system. Orthologous to human RNF186 (ring finger protein 186). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf186 |
| Official Name | ring finger protein 186 [Source:MGI Symbol;Acc:MGI:1914075] |
| Ensembl ID | ENSMUSG00000070661 |
| Bio databases IDs | |
| Aliases | ring finger protein 186 |
| Synonyms | 9130020G10Rik, LOC684585, ring finger protein 186 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf186 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf186 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K29-linked ubiquitination
- protein localization in mitochondrion
- regulation of autophagic vacuole assembly
- protein K63-linked ubiquitination
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding