OTUD5 Gene Summary [Human]
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | OTUD5 |
| Official Name | OTU deubiquitinase 5 [Source:HGNC Symbol;Acc:HGNC:25402] |
| Ensembl ID | ENSG00000068308 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase 5, deubiquitinase A |
| Synonyms | BB114028, DKFZp761A052, DUBA, DXImx46e, MCAND, OTU deubiquitinase 5, OTU domain containing 5, Sfc7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OTUD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin binding domain
- ubiquitin-specific protease
- enzyme
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute kidney injury
- X-linked multiple congenital anomalies-neurodevelopmental syndrome
- hereditary disorder
- neurodegeneration with brain iron accumulation type 5
role in cell
- expression in
- migration
- phosphorylation in
- proliferation
- invasion by
- production in
- differentiation
- quantity
- binding in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OTUD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- protein deubiquitination
- negative regulation of type I interferon production
- neural crest cell differentiation
- proteolysis
- response to lipopolysaccharide
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity