TAF7 Gene Summary [Human]
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | TAF7 |
| Official Name | TATA-box binding protein associated factor 7 [Source:HGNC Symbol;Acc:HGNC:11541] |
| Ensembl ID | ENSG00000178913 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 7 |
| Synonyms | TAF2F, TAFII55, TATA-box binding protein associated factor 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- protein binding activity, bridging
- vitamin D receptor binding
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- TATA binding protein associated factor 7
- sequence-specific DNA binding
- thyroid hormone receptor binding
- binding protein
- double-stranded DNA binding
- protein heterodimerization
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the TAF7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- growth
- phosphorylation in
- expression in
- production in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- negative regulation of MHC class II biosynthetic process
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- negative regulation of MHC class I biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein kinase activity
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- spermine transport
- RNA polymerase II transcriptional preinitiation complex assembly
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- transcription factor TFIID complex
- transcription factor TFTC complex
- cytoplasm
- nucleoplasm
- MLL1 complex
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase binding
- protein binding
- TFIIH-class transcription factor binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- vitamin D receptor binding
- transcription regulatory region sequence-specific DNA binding
- thyroid hormone receptor binding