GADD45GIP1 Gene Summary [Human]
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | GADD45GIP1 |
| Official Name | GADD45G interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29996] |
| Ensembl ID | ENSG00000179271 |
| Bio databases IDs | |
| Aliases | GADD45G interacting protein 1, papillomavirus L2 interacting nuclear protein 1, CKII beta binding protein 2, CR6 interacting factor 1, p53-responsive gene 6 |
| Synonyms | 2310040G17Rik, CKBBP2, CKbetaBP2, CRIF1, GADD45G interacting protein 1, growth arrest and DNA-damage-inducible, gamma interacting protein 1, growth arrest and DNA-damage-inducible, γ interacting protein 1, mL64, MRP-L59, p53 RESPONSIVE GENE 6, PLINP, PLINP-1, PRG6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GADD45GIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- osteosarcomagenesis
- breast cancer
- osteosarcoma
- growth failure
role in cell
- quantity
- expression in
- proliferation
- phosphorylation in
- apoptosis
- growth
- degradation in
- fragmentation
- fragmentation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GADD45GIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding