GADD45G Gene Summary [Human]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GADD45G |
| Official Name | growth arrest and DNA damage inducible gamma [Source:HGNC Symbol;Acc:HGNC:4097] |
| Ensembl ID | ENSG00000130222 |
| Bio databases IDs | |
| Aliases | growth arrest and DNA damage inducible gamma, gadd-related protein, 17 kD, growth arrest and DNA-damage-inducible gamma |
| Synonyms | CR6, DDIT2, GADD45gamma, Gadd45-γ, Growth Arrest And DNA Damage Inducible, growth arrest and DNA-damage-inducible 45 gamma, growth arrest and DNA-damage-inducible 45 γ, growth arrest and DNA damage inducible gamma, growth arrest and DNA-damage-inducible, gamma, growth arrest and DNA damage inducible γ, growth arrest and DNA-damage-inducible, γ, GRP17, OIG37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GADD45G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the GADD45G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- Ullrich congenital muscular dystrophy
- organismal death
- infertility condition
- androgenic alopecia
- acute myeloid leukemia
- systemic lupus erythematosus
- secondary sex reversal
- FLT3 internal tandem duplication positive acute myeloid leukemia
- delayed hypersensitive reaction
role in cell
- expression in
- accumulation
- apoptosis
- proliferation
- activation in
- quantity
- growth
- phosphorylation in
- differentiation
- daunorubicin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GADD45G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- apoptotic process
- positive regulation of apoptotic process
- cell differentiation
- regulation of cell cycle
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding