CLK3 Gene Summary [Human]
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CLK3 |
| Official Name | CDC like kinase 3 [Source:HGNC Symbol;Acc:HGNC:2071] |
| Ensembl ID | ENSG00000179335 |
| Bio databases IDs | |
| Aliases | CDC like kinase 3 |
| Synonyms | AI256811, CDC-like kinase 3, LOC102723772, PHCLK3, PHCLK3/152 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
- Tyrosine kinase, catalytic domain
- identical protein binding
Pathways
Biological processes and signaling networks where the CLK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- cholangiocarcinoma cancer
- bile duct cancer
- biliary tract cancer
- pancreaticobiliary cancer
- epithelial neoplasia
- digestive system cancer
- abdominal cancer
- cholangiocarcinoma
role in cell
- survival
- expression in
- apoptosis
- phosphorylation in
- binding in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intermediate filament cytoskeleton
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intermediate filament cytoskeleton
- nuclear speck
- acrosomal vesicle
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- identical protein binding
- protein binding
- RNA binding
- protein serine/threonine/tyrosine kinase activity
- protein serine/threonine kinase activity