GMPS Gene Summary [Human]
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GMPS |
| Official Name | guanine monophosphate synthase [Source:HGNC Symbol;Acc:HGNC:4378] |
| Ensembl ID | ENSG00000163655 |
| Bio databases IDs | |
| Aliases | guanine monophosphate synthase, GMP synthase |
| Synonyms | GATD7, Gm9479, guanine monophosphate synthase, guanine monophosphate synthetase, Guanine Monphosphate Synthetase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GMPS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase C26
- GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit
- Glutamine amidotransferase class-I
- GMP synthase (glutamine-hydrolysing)
- GMP synthase
- enzyme binding
- enzyme
- GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit
- Type 1 glutamine amidotransferase (GATase1)-like domain
- Adenine nucleotide alpha hydrolase (AANH) superfamily
- GMP synthase C terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GMPS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine metabolic process
- purine base biosynthetic process
- GMP biosynthetic process
- purine ribonucleoside monophosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- GMP synthase activity
- GMP synthase (glutamine-hydrolyzing) activity