USP13 Gene Summary [Human]
Enables several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP13 |
| Official Name | ubiquitin specific peptidase 13 [Source:HGNC Symbol;Acc:HGNC:12611] |
| Ensembl ID | ENSG00000058056 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 13, isopeptidase T-3 |
| Synonyms | 2700071E21RIK, AI848077, ISOT3, ubiquitin specific peptidase 13, ubiquitin specific peptidase 13 (isopeptidase T-3), UBIQUITIN SPECIFIC PROTEASE 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- peptidase
- enzyme binding
- ubiquitin binding
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
- Variant UBP zinc finger
- cysteine endopeptidase
- binding protein
- Zn-finger in ubiquitin-hydrolases and other protein
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- chaperone binding
- ubiquitin-like-specific protease
- ubiquitin-specific thiol-proteases domain
Pathways
Biological processes and signaling networks where the USP13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- organismal death
- Huntington disease
- acute myeloid leukemia
- grade 1 cervical intraepithelial neoplasia
- cervical cancer
- gastric cancer
- grade 2 and 3 cervical intraepithelial neoplasia
role in cell
- expression in
- activation in
- proliferation
- growth
- production in
- apoptosis
- interaction in
- binding in
- differentiation
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- synaptosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- protein deubiquitination
- melanocyte differentiation
- autophagy
- regulation of autophagy
- proteolysis
- regulation of transcription, DNA-dependent
- protein K6-linked deubiquitination
- protein stabilization
- protein K29-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- ubiquitin protein ligase binding
- protein binding
- proteasome binding
- ubiquitin binding
- chaperone binding
- cysteine-type endopeptidase activity
- small conjugating protein ligase binding