AATK Gene Summary [Human]
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | AATK |
| Official Name | apoptosis associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:21] |
| Ensembl ID | ENSG00000181409 |
| Bio databases IDs | |
| Aliases | apoptosis associated tyrosine kinase, lemur tyrosine kinase 1, protein phosphatase 1, regulatory subunit 77 |
| Synonyms | AATYK, AATYK1, apoptosis-associated tyrosine kinase, KIAA0641, LMR1, LMTK1, LOC100292717, LOC688299, mKIAA0641, p35BP, PPP1R77 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AATK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- p35 binding domain
- Protein tyrosine and serine/threonine kinase
- tyrosine kinase domain
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the AATK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neurotic disorder
- depressive disorder
- neuroticism
- major depression
- metabolic syndrome X
- Alzheimer disease
- infection by vesicular stomatitis virus
regulated by
- 5-hydroxytryptamine
- L-triiodothyronine
- diethylnitrosamine
- metformin
- phenobarbital
- tretinoin
- phosphoenolpyruvate
- troglitazone
- TNF
- 32dcl cells
role in cell
- expression in
- apoptosis
- outgrowth
- abnormal morphology
- outgrowth in
- elongation in
- transport in
- elongation
- stabilization in
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- growth cone
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AATK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine autophosphorylation
- brain development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity