GINS3 Gene Summary [Human]
This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | GINS3 |
| Official Name | GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:25851] |
| Ensembl ID | ENSG00000181938 |
| Bio databases IDs | |
| Aliases | GINS complex subunit 3 |
| Synonyms | 2700085M18Rik, FLJ13912, GINS complex subunit 3, LOC688952, PSF3, RGD1308153 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GINS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-helical domain of GINS complex proteins (Sld5, Psf1, Psf2 and Psf3)
- GINS_B
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GINS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- CMG complex
- GINS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding